Engineering CSFe Bond Confinement Effect to Stabilize Metallic-Phase Sulfide for High Power Density Sodium-Ion Batteries.

Metallic-phase iron sulfide (e.g., Fe7 S8 ) is a promising candidate for high power density sodium storage anode due to the inherent metal electronic conductivity and unhindered sodium-ion diffusion kinetics. Nevertheless, long-cycle stability can not be achieved simultaneously while designing a fast-charging Fe7 S8 -based anode. Herein, Fe7 S8 encapsulated in carbon-sulfur bonds doped hollow carbon fibers (NHCFs-S-Fe7 S8 ) is designed and synthesized for sodium-ion storage. The NHCFs-S-Fe7 S8 including metallic-phase Fe7 S8 embrace higher electron specific conductivity, electrochemical reversibility, and fast sodium-ion diffusion. Moreover, the carbonaceous fibers with polar CSFe bonds of NHCFs-S-Fe7 S8 exhibit a fixed confinement effect for electrochemical conversion intermediates contributing to long cycle life. In conclusion, combined with theoretical study and experimental analysis, the multinomial optimized NHCFs-S-Fe7 S8 is demonstrated to integrate a suitable structure for higher capacity, fast charging, and longer cycle life. The full cell shows a power density of 1639.6 W kg-1 and an energy density of 204.5 Wh kg-1 , respectively, over 120 long cycles of stability at 1.1 A g-1 . The underlying mechanism of metal sulfide structure engineering is revealed by in-depth analysis, which provides constructive guidance for designing the next generation of durable high-power density sodium storage anodes.

LncRNAs signatures associated with cuproptosis predict the prognosis of endometrial cancer.

Background: Endometrial cancer (UCEC) is the sixth most common cancer in women, and although surgery can provide a good prognosis for early-stage patients, the 5-year overall survival rate for women with metastatic disease is as low as 16%. Long non-coding RNAs (LncRNAs) are thought to play an important role in tumor progression. Cuproptosis is a recently discovered form of cell death in which copper binds directly to the lipoacylated component of the tricarboxylic acid (TCA) cycle. The aggregation of these copper-bound listed mitochondrial proteins and the loss of Fe-S cluster proteins trigger proteotoxic stress, which leads to cell death. Therefore, the aim of this work was to investigate the role of Cuproptosis-related LncRNAs signaling in clinical prognostic prediction and immunotherapy, as well as the relationship between tumor mutation burden. Methods: Genomic, clinical and mutational data of endometrial cancer patients were presented in the TCGA database, and cuproptosis-related genes obtained from related studies. Coexpression analysis and Cox regression analysis were used to construct prognostic features. Patients were divided into high risk group and low risk group, and then ROC, survival rate, risk curve, principal component analysis, independent prognostic analysis and clinical subgroup model validation were performed to observe the prognostic value of characteristics. Subsequently, the GO and genomic KEGG enrichment and immune-related functions of LncRNAs as well as the tumor mutation burden were analyzed. Results: In 548 UCEC case data, we identified five associated LncRNAs co-expressed with cuproptosis genes, and we found that high-risk patients had poorer overall survival (OS), progression-free survival (PFS), and higher mortality. Independent prognostic analysis, ROC showed that the LncRNAs associated with cuproptosis could accurately predict the prognosis of patients. Enrichment analysis revealed that the biological functions of LncRNAs were related to tumorigenesis. We also discovered suppression of immune-related functions in high-risk patients with oncogene mutations, higher tumor mutation burden in low-risk patients, and longer overall survival in patients with higher tumor mutation burden. Conclusion: The identification of five LncRNAs associated with cuproptosis can accurately predict the prognosis of patients with endometrial cancer, and may provide a new perspective for clinical application and immunotherapy.

The efficacy of mifepristone combined with methotrexate for the treatment of ectopic pregnancy: a systematic review and meta-analysis.

OBJECTIVE: Systematically evaluate the clinical efficacy of mifepristone combined with methotrexate therapy for ectopic pregnancy (EP), analyze the experimental designs, put forward improvement ideas. METHODS: RCTs of mifepristone combined with mifepristone for EP until January 2022 in six databases were searched. The primary outcome indicator was the cure rate. RevMan 5.4 was used to analyse and the online GRADEpro tool was used to assess the certainty of the evidence. RESULTS: Twenty-five RCTs involved 2263 patients. The cure rate was higher in the investigational group (OR = 4.09, 95%CI: [3.20, 5.22]), time of vagina stopped bleeding (MD = -11.21, 95%CI: [-11.85, -10.57]) and time of abdominal pain disappeared (MD = -6.24, 95%CI: [-6.63, -5.86]) were shorter in the investigational group, ß-HCG level (MD = -585.32, 95%CI: [-609.62, -561.03]) was lower and diameter of the mass (MD = -1.23, 95%CI: [-1.40, -106]) was smaller in the investigational group. The certainty of the evidence for most outcomes was moderate or high, and only one was low. CONCLUSIONS: The combination of mifepristone and methotrexate can improve the efficacy of ectopic pregnancy without amplifying the toxic side effects. Larger scale and better design of the randomized controlled trials are needed.KEY MESSAGESIn recent years, the increase in ectopic pregnancies and their impacts on female fertility makes physicians have to find an effective medical treatment as soon as possible that can avoid surgery.The mifepristone combined with methotrexate therapy for EP has better curative effects on improving the cure rate, lowering ß-HCG level, reducing the mass, and alleviating symptoms of abdominal pain and bleeding, without amplifying the toxic side effects.Literature with high quality is lacking, and well-designed, large-scale and high-quality multicenter randomized controlled trials are needed.

Highly stable cathodes for proton exchange membrane fuel cells: Novel carbon supported Au@PtNiAu concave octahedral core-shell nanocatalyst.

Despite the remarkable research efforts, the lack of ideal activity and state-of-the-art electrocatalysts remains a substantial challenge for the global application of fuel cell technology. Herein, is reported the synthesis of Au@PtNiAu concave octahedral core-shell nanocatalysts (Au@PtNiAu-COCS) via solvothermal synthesis modification and optimization approach. The special structure generating a large number of step atoms, enhancing the oxygen reduction reaction (ORR) and methanol oxidation reaction (MOR) activity and stability. The superior ORR mass activity of the Au@PtNiAu-COCS is 11.22 times than the exhibited of Pt/C initially by Pt loading, and 5.11 times by Pt + Au loading. After 30 k cycles the mass activity remains 78.8% (8.83 times the initial Pt/C activity) and the half-wave potential only shifts 12 mV. Au@PtNiAu-COCS has superior half-cell activity and gives ideal membrane electrode assemblies. Furthermore, for MOR the Au@PtNiAu-COCS show enhanced anti-toxic (tolerant) ability in CO. This work provides a new strategy to develop core-shell structure nanomaterials for electrocatalysis.

The Efficacy of the Yasmin[Ethinylestradiol-Drospirenone (0.03/3 mg)] Treatment for Postoperative Abortion: A Protocol of Meta-Analysis.

Background: Induced abortion is a universal phenomenon and about 25% of pregnancies in the world end in induced abortion. Induced abortion refers to the use of artificial or drug methods to terminate the pregnancy in the early stage of pregnancy, which is a remedy for failed contraception and accidental pregnancy. Induced abortion means surgical abortion. There are two commonly used methods: negative pressure suction abortion and forceps curettage for induced abortion. Abortion is invasive and it will cause great harm to women's reproductive function. Clinically, there are also cases of re-pregnancy within 3 months after abortion or even re-pregnancy without recovery of menstruation. To improve symptoms and reduce these complications, antibiotics, motherwort, and Yasmin[Ethinylestradiol-Drospirenone (0.03/3 mg)] are clinically used alone or in combination after induced abortion. Methods: Data were collected from six databases, including three English databases of Cochrane Library, PubMed and Embase, and three Chinese databases of CNKI, Wanfang, and Weipu. The original indicators of vaginal bleeding, menstrual recovery time, bleeding time, endometrial thickness 21 days after surgery and so on were included, and the incidence of postoperative bleeding less than menstrual volume, menstrual re-fluid time ≤ 37 days, bleeding time ≤ 7 days, re-pregnancy without menstruation, re-pregnancy within 3 months after the operation, the total incidence of postoperative complications were based on the ratio of the number of events in the group to the total number of people in the group reported in the literature. Review Manager 5.4 software was downloaded from the Cochrane website to evaluate the quality of the literature and analyze the results using random or fixed-effects models. The outcome of index data is divided into two types, one is dichotomy, and the other is measurement data. The binary data is expressed by odds ratio (OR), and the measurement data is expressed by mean difference (MD), and the confidence interval of both is 95%. Results: After completing this meta-analysis, the results will be available. Conclusion: The results will provide reliable data basis for the value of Yasmin combined with antibiotics and Motherwort in postoperative induced abortion. PROSPERO Registration Number: CRD42021246764.

Silver(I) Complexes of Diphenylpyridines: Crystal Structures, Luminescence Studies, Theoretical Insights, and Biological Activities.

A series of simple two-coordinated cationic silver(I) complexes, namely, [Ag{4-(4-R1 -phenyl)-2,6-diphenylpyridine}2 ]X (X=ClO4 - , BF4 - , or SO3 CF3 - ), with different electron-donating or -withdrawing groups (e.g., R1 =N(Me)2 , Me, H, Cl, and Br) on the phenyl ring, were successfully prepared. Extensive characterization of these complexes by various NMR spectroscopy techniques and mass spectrometry was further corroborated by single-crystal XRD analyses. Detailed photophysical investigations of [Ag{4-(4-N,N-dimethylaminophenyl)-2,6-diphenylpyridine}2 ]ClO4 (C1) displayed a strong room-temperature fluorescence in solution with an anomalously high luminescence quantum yield of 0.83. The effects of distinct substituent groups (C2-C5), π-conjugated aromatic rings (C6 and C7), and anions (C8 and C9) on the photoluminescence properties were evaluated. Furthermore, DFT and time-dependent DFT calculations were performed to discern the composition of the excited state, as well as to confirm the obtained relative emission energies upon substitution with electronically different ligands. These results indicated that the strong electron-donating substituent of N,N-dimethylamine played an important role in the unprecedented high luminescence quantum yield of C1. In addition, preliminary antimicrobial studies and confocal microscopy fluorescent imaging of HeLa cells labeled with these complexes reveal their potential applications in biological activities.